A 57-year-old man with end-stage heart disease who underwent surgery
On the 10th, the University of Maryland in the United States succeeded in the world's first surgery to transplant a pig's heart into a human. [Video] A man who underwent transplant surgery , a 57-year-old man with end-stage heart disease who underwent two-shot (around 10 seconds) surgery with a surgeon . The man said the day before surgery, "I had to get this transplant if I didn't want to die. I wanted to live. I knew the danger, but that was my last choice." Three days have passed since the operation, but the condition is said to be good. Pigs have undergone operations such as removing genes that cause rejection, and it is the first time that the animal's heart functions in the human body and does not cause immune rejection. "We are one step closer to solving the problem of organ shortages, and we hope that the world's first surgery will be a new option for future patients," said the surgeon.
The world's first successful transplant ... What is the impact on other organs?
According to the US Department of Health Resources, about 110,000 people in the country are waiting for organ transplants, and research on transplantation of pig hearts and kidneys, which are similar to human organs, is underway. Sachiko Takahashi , CEO of Genequest, Japan's first large-scale genetic testing and analysis service for individuals, is surprised at this news. "Human transplantation of animal organs has been studied for a long time, but it was thought that it would be quite difficult to put it to practical use due to problems such as immune rejection. This time, we eliminated the genes involved in immune rejection and accepted it by humans. I'm transplanting after putting an immune gene into a pig so that it can be transplanted. I agreed. This time, I will transplant and live with the organ. I didn't think it would happen so quickly. "(Mr. Shoko Takahashi)
Ambiguous "whether pig or human" boundary?
Last October, a team of Langone Health surgeons at New York University announced a successful pig-to-human kidney transplant . The transplanted new kidney was connected to the blood vessels of a brain-dead patient and maintained in vitro for 3 days. Even in the transplant surgery at this time, the gene of the pig was manipulated to remove the molecule that causes rejection. The patient's family agreed to the experiment shortly before the brain-dead patient was removed from life support. Organ transplantation from pigs to humans, which is attracting worldwide attention. Is the size of the organs balanced? Mr. Takahashi said, "I think the pig's heart is a relatively acceptable (sized) organ that resembles the size of a human. Transplantation from other animals is also being studied, but this time," Pig Isn't it the most suitable? ” On the other hand, Mr. Takahashi said, "Pig's memory will never enter humans." "How does the pig's heart affect other organs? It is unknown, so there is no effect." I can't say that. What will happen to patients in the future? Can they live in good health? It will be the “first step” for important data. ” Will the use of livestock organs be accepted by humans in the future? Also, is there any ethical problem? "In this case, I had no choice but to die or transplant. As a result, I did a transplant and it has been successful so far, so it's a good case, but last year's brain death condition. In the case of patients, there are questions such as "what can I do if I am in a state of brain death" and "can I use it to test the safety (of transplantation)?" Recently, among pigs, humans There is also research on making organs. When that happens, the boundaries between where the pigs are and where the humans are are becoming ambiguous. It can be technically done, but how far can it be done? There is an ethical question. I think it will occur more and more. "(" ABEMA Hills"Than)
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