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Cancer also has a weakness. That is that it is "heat sensitive. Cancer cells begin to die at a temperature of about 43°C degrees Celsius.
1. Cell survival curve by heatingSurvival curve2. Change in blood flow in cancerous tissue and normal tissue by heatingChange in blood flow in cancerous tissue and normal tissue by heating
See the graph in 1. The survival rate of cancer cells decreases drastically when the temperature exceeds 42.5°C. The graph in 2 shows that the survival rate of cancer cells decreases drastically when the temperature exceeds 42.5°C.
The graph in 2 shows that the blood flow of cancer cells hardly increases even though the temperature rises. The skin and muscle areas continue to increase blood flow beyond 42.5°C to around 45°C due to vasodilation, but the cancerous areas do not increase blood flow because the blood vessels do not dilate. In other words, cancer cells have a weak "heat" release mechanism.
It can be said that cancer cells easily warm up and are vulnerable to heat.
Treatment using heat
There is already a long history of treatments that take advantage of the "heat-sensitive" nature of cancer.
Hyperthermia is a treatment in which the affected area is heated to 42°C to 44°C degrees Celsius for 30 minutes to 60 minutes. The origin of this method can be traced back to 1866, when Dr. W. Busch (Germany) reported the disappearance of tumors by hyperthermia. In 1975, the first international symposium was held in Washington, D.C., marking the first step toward a new cancer treatment method.
In Japan, the Japanese Society of Hyperthermia was established in 1984.
Modern hyperthermia also uses microwaves, radio waves, and lasers. However, all of these methods make it difficult to control the temperature and range of localization of cancer, which may lead to unexpected adverse events.
On the other hand, it has been found that warming only to about 43 degrees Celsius may cause subsequent cancer recurrence or metastasis.
Heating cancer cells to about 60°C degrees Celsius
Based on the research, achievements, and cooperation of Ehime University's Faculty of Medicine and Faculty of Engineering, Admetec has found a treatment method that overcomes the current issues and risks as much as possible. The new method is a device and method that enables "reliable heat input to the treatment site," "precise temperature control," and "reliable cell death of cancer cells.
It is a device and method that enables "reliable heat input to the treatment site," "precise temperature control," and "reliable cell death of cancer cells." A microscopic heating needle is guided by CT and echography to reach and heat the affected cancer site. No general anesthesia is required.
If the affected area is large, multiple needles are reached. Next, a microscopic heater at the tip of the needle is used to control the temperature of the affected area to approximately 60 degrees Celsius for a certain period of time.
After further heating, immune cells such as dendritic cells and CTLs are inserted into the weakened cancer cells to post antigens. In this way, immune cells learn the enemy cancer cells and attack the cancer scattered throughout the body.
Features
Minimally invasive (less burden on the patient)
Economical and effective
Cauterization area and temperature can be strictly controlled.
Outpatient or short-term hospitalization
Repeatable
Thermal (cryoablation) therapy and immuno-cell therapy
For the general public
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Cancer is sensitive to "heat
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